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The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.
Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | healthy volunteer between age of 20 to 55 will undergo MRI examination. |
| |
| ADHD subjects without medication | Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination. |
| |
| ADHD subjects with medication | Subjects with ADHD (20-55 years), under medication will undergo MRI examination. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Device | Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in blood oxygenation level dependency (BOLD) | The study consist solely of one MRI examination performed within 2 hours. | 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Three groups:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kantonsspital Aarau | Aarau | Canton of Aargau | 5001 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33740903 | Derived | Berberat J, Huggenberger R, Montali M, Gruber P, Pircher A, Lovblad KO, Killer HE, Remonda L. Brain activation patterns in medicated versus medication-naive adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching. BMC Med Imaging. 2021 Mar 19;21(1):53. doi: 10.1186/s12880-021-00579-3. |
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| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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