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The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.
This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with chronic superficial gastritis | Patients with chronic superficial gastritis |
| |
| Patients with chronic atrophic gastritis | Patients with chronic atrophic gastritis |
| |
| Patients with gastric carcinoma | Patients with gastric carcinoma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| different diseases | Diagnostic Test | Patients will be divided into three groups, including chronic superficial gastritis ,chronic atrophic gastritis and gastric carcinoma. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metabonomic difference in patients with chronic gastritis and gastric carcinoma | 1.The different levels of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma. 2. The common change model of metabolites in gastric carcionoma compared with chronic gastritis. | six months |
| Measure | Description | Time Frame |
|---|---|---|
| Association of different metabolic substances and disease results in chronic gastritis and gastric carcinoma | The researchers want to reveal the relationship between different metabolic sustances and disease result in patientswith chronic gastritis and gastric carcinoma. | six months |
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Inclusion Criteria:
Exclusion Criteria:
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We will enroll patients with chronic superficial gastritis, chronic atrophic gastritis or gastric carcinoma.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuehua Han, Dr. | Contact | +86 13858126927 | 13858126927@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yuehua Han, Dr. | 2nd Affiliated Hospital, School of Medicine, Zhejiang university, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Affiliated Hospital, School of Medicine | Recruiting | Hangzhou | Zhejiang University | 310000 | China |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |