Metabonomics Study of Chronic Gastritis and Gastric Carcinoma

Metabonomics Study of Chronic Gastritis and Gastric Carcinoma

The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.

This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.

Inclusion Criteria:

• Patients with chronic superficial gastritis and chronic atrophic gastritis
• Patients with gastric carcinoma

Exclusion Criteria:

• Patients with history of surgery
• Patients with severe heart disease,lung disease or kidney disease.