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This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.
The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.
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| Measure | Description | Time Frame |
|---|---|---|
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit |
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |
| Measure | Description | Time Frame |
|---|---|---|
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit |
| Diffusing capacity for nitric oxide (DLNO) |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy people without chronic cardiopulmonary diseases will be invited to participate in this study.
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| Name | Affiliation | Role |
|---|---|---|
| Thomas Radtke, PhD | University of Zurich and University Hospital Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Zurich and University Hospital of Zurich | Zurich | 8001 | Switzerland |
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DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.
| At third study visit, approximately 1-2 weeks after second study visit |
| Diffusing capacity for carbon monoxide (DLCO) | DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit |
| Diffusing capacity for carbon monoxide (DLCO) | DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |
| Diffusing capacity for carbon monoxide (DLCO) | Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit |
| Diffusing capacity for carbon monoxide (DLCO) | Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |
| Alveolar volume (VA) | VA (in L) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit |
| Alveolar volume (VA) | VA (in L) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |
| Alveolar volume (VA) | Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit |
| Alveolar volume (VA) | Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |
| Breath hold time (BHT) | BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit |
| Breath hold time (BHT) | BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |
| Breath hold time (BHT) | BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit |
| Breath hold time (BHT) | BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit |