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The measurement of nitric oxide lung diffusing capacity (DLNO) has been recently standardised. To date, two pulmonary function devices are commercially available and are used for the measurement of DLNO. No previous study assessed differences in gas exchange outcomes (e.g., DLNO values) between both devices.
The aim of this project is to compare two commercially available devices that measure lung diffusing capacity for nitric oxide (DLNO).
In a single-center, crossover study conducted at the University Hospital Zurich, Switzerland, 35 healthy, non-smoking adults (>=18 years) will be invited to perform DLNO measurements in random order using the MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium) devices during one study visit.
The order of the tests on the MasterscreenTM and HypAir devices will be randomly allocated using central randomisation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lung diffusing capacity measurements | Participants perform single-breath lung diffusing capacity measurements in random order during one study visit. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Jaeger Masterscreen TM | Device | Single-breath nitric oxide lung diffusing capacity |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference in nitric oxide lung diffusing capacity (mL/min/mmHg) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in carbon monoxide lung diffusing capacity (mL/min/mmHg) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in Alveolar volume (L) |
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Inclusion Criteria:
- Age 18 years and older
Exclusion Criteria:
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Healthy people
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| Name | Affiliation | Role |
|---|---|---|
| Thomas Radtke, PhD | University of Zurich, EBPI, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Zurich and University Hospital of Zurich | Zurich | 8001 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28179436 | Result | Zavorsky GS, Hsia CC, Hughes JM, Borland CD, Guenard H, van der Lee I, Steenbruggen I, Naeije R, Cao J, Dinh-Xuan AT. Standardisation and application of the single-breath determination of nitric oxide uptake in the lung. Eur Respir J. 2017 Feb 8;49(2):1600962. doi: 10.1183/13993003.00962-2016. Print 2017 Feb. |
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| HypAir Medisoft | Device | Single-breath nitric oxide lung diffusing capacity |
|
Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium).
| 1 hour |
| Difference in inspiratory volume (L) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in breath-hold time (s) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in inspired concentrations for nitric oxide (in %) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in expired concentrations for nitric oxide (in %) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in inspired concentrations for carbon monoxide (in %) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in expired concentrations for carbon monoxide (in %) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in inspired concentrations for helium (%) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in expired concentrations for helium (%) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 day |
| Difference in inspired concentrations for oxygen (%) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |
| Difference in expired concentrations for oxygen (%) | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). | 1 hour |