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In the prospective, randomized, controlled multi-centre study, 100 patients who were clinically diagnosed with sarcopenia were assigned to either a home-based exercise group or the control group. The home-based exercise program was performed three days per week for 12 weeks. Before and three months after the exercise program, all the patients were evaluated.
Sarcopenia is a complex and multifactorial syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength.The randomized, multicenter study was conducted at the physical medicine and rehabilitation departments of five different centers. One hundred patients met the inclusion and exclusion criteria and were randomly allocated to either a home-based exercise group (n=50) or a control group (n=50). The patients were evaluated before and 3 months after inclusion using the timed up and go test, the Berg balance scale, the 6-minute walk test , a numeric rating scale to determine QoL, and the number of falls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise group | Experimental | The home-based training program |
|
| control group | No Intervention | All patients participated in a one-session educational program conducted by the investigators at each clinic. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Home based exercise | Other | The home-based training program included posture and stretching exercises, strengthening exercises, balance training, and a walking regimen 3 days per week for 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline timed up and go test at 3-months | The timed up and go test test measures the amount of time needed for a patient to stand up from a chair, walk three meters as quickly and safely as possible toward a cone, walk around it, and sit down on the chair again. | Baseline, 3-month |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline Berg balance scale score at 3-months | The Berg balance scale is a reliable tool for assessing balance and postural control in older adults. This scale consists of 14 items, each scored from 0 to 4, with a maximal score of 56 points. A higher score indicates better balance | Baseline, 3-month |
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Inclusion Criteria:
community-dwelling older adult diagnosis of sarcopenia according to the clinical examination; and able to walk independently. The physical performance of patients with a SARC-F score ≥4 were tested using a gait speed test and a short physical performance battery (SPPB). The diagnosis of sarcopenia was confirmed in cases where the patient's gait speed was ≤0.8 m/s and the SPPB score was ≤8
Exclusion Criteria:
having cardiovascular, pulmonary, and/or chronic diseases that may affect participation in the exercise program; impaired cognition; previous diagnosis of a neurological condition that severely affected mobility and balance; malignancy; metastatic cancer; serious vision loss or vestibular impairment
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| Name | Affiliation | Role |
|---|---|---|
| Ayse Karan, Professor | Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Balikesir University Faculty of Medicine, Department of Physical Therapy and Rehabilitation | Balıkesir | Turkey (Türkiye) | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34271551 | Derived | Sen EI, Eyigor S, Dikici Yagli M, Ozcete ZA, Aydin T, Kesiktas FN, Aydin FY, Vural M, Sahin N, Karan A. Effect of Home-Based Exercise Program on Physical Function and Balance in Older Adults With Sarcopenia: A Multicenter Randomized Controlled Study. J Aging Phys Act. 2021 Jul 16;29(6):1010-1017. doi: 10.1123/japa.2020-0348. |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Change from baseline 6-minute walk test (6MWT) at 3-months |
The 6MWT is used to assess people's physical capacity. participants were asked to walk back and forth in a hospital corridor free of obstacles for 6 minutes at a regular pace. |
| Baseline, 3-month |
| Change from baseline self-reported QoL at 3-months | The average level of QoL was evaluated using the numeric scale and scored between 0 and 10, where 0 indicates the best QoL and 10 indicates the worst QoL | Baseline, 3-month |
| Change from baseline number of falls at 3-months | The number of falls was monitored by monthly telephone calls | Baseline, 3-month |
| Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital |
| Istanbul |
| Turkey (Türkiye) |
| Istanbul Physical Medicine and Rehabilitation Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation | Istanbul | Turkey (Türkiye) |
| Ege University Faculty of Medicine, Department of Physical Medicine and Rehabilitation | Izmir | Turkey (Türkiye) |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |