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Sarcopenia is a pathophysiological process associated with aging and some metabolic conditions characterized by progressive muscle tissue loss, which may lead to loss of strangth and performance and increase risk of falls and fractures, physical disability and premature death. Therefore, it is necessary to identify personalized programs of physical activity and supplementation for elderly population in order to improve their physical functions, muscle strengh and body composition.
With the present project we aime to assess the effect of a feasible home-based exercise program coupled with food supplementation to improve muscle strength, muscle volume and muscle physical performance potentially associated with sarcopenia in elderly people.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physical activity group | Experimental |
| |
| Physical activity and supplementation group | Experimental |
| |
| Control group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical activity | Behavioral | Home-based physical activity program |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Lower limb strength | Assessed by chair stand test | Baseline and Week 24 |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Assessed by Whole-body dual energy X-ray absorptiometry | Baseline and Week 24 |
| Quantify thigh cross sectional area | Assessed by Dixon magnetic resonance imaging |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Istituto Ortopedico Galeazzi | Milan | 20141 | Italy |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 20, 2025 | |
| Reset | Feb 11, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 20, 2025 | Feb 11, 2025 |
| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D019587 | Dietary Supplements |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Physical activity and supplementation |
| Dietary Supplement |
Home-based physical activity program and amminoacid supplementation |
|
| Control | Other | No intervention |
|
| Baseline and Week 24 |
| Maximum isometric force that a hand can squeeze | Assessed by Hand Grip Strength test | Baseline and Week 24 |
| Maximal Isometric Strength of Knee flexors and extensors | Assessed by a belt-stabilized dynamometer | Baseline AND Week 24 |
| Dynamic balance and gait deficits | Assessed by mini-BESTest | Baseline and Week 24 |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |