Combined Exercise and Nutrition Intervention for Possible Sarcopenia Among Older Adults in Primary Care

Combined Exercise and Nutrition Intervention for Possible Sarcopenia Among Community-dwelling Older Adults in Primary Care: A Randomized Controlled Trial

The purpose of this study is to assess the impact of a combined exercise-nutrition intervention in primary clinics on sarcopenia indices, physical function, and quality of life in community-dwelling older adults with possible sarcopenia.

This study will investigate the effects of a 12-week combined exercise-nutrition intervention by comparing it with a control group receiving standard care (usual care) by assessing the sarcopenia indicators, functional recovery, and individual satisfaction. This is an interventional clinical study designed to recruit subjects, analyze data, identify problems, find improvement areas, and explore potential solutions.

Inclusion Criteria:

• 65 to 85 years of age

• Men and women with possible sarcopenia

  • If included in the possible sarcopenia criteria in the 2019 Asian Working Group for Sarcopenia(AWGS) criteria A Simple Questionnaire to Rapidly Diagnose Sarcopenia(The Korean SARC-F questionnaire) score is 4 or higher; or Calf circumference (Men's: <34 cm, Women's: <33 cm) + Decreased muscle strength (male: <28kg, female: <18kg) or Decreased physical function (if it takes more than 12 seconds from the 5-chair stand test)
  • [(1) and {(2) or (3)}]

Exclusion Criteria:

• Renal failure: Serum creatine exceeding 2.0 mg/dl
• Uncontrolled hypertension: systolic/diastolic blood pressure greater than 150/90 millimeter of mercury(mmHg)
• Uncontrolled diabetes: glycated hemoglobin (HbA1C) over 7.5%
• Subject who are receiving treatment (steroids, anticancer drugs, etc.) that can affect muscle mass
• Subjects with myocardial infarction or angina pectoris, stroke disease
• Malignant tumor: Subject who has a history of cancer within 5 years or is currently receiving treatment
• Subjects who have liver cirrhosis and uncontrolled hepatitis (Aspartate aminotransferase or Alanine aminotransferase is more than three times the upper limit of the reference range)
• Subjects who have chronic diseases such as musculoskeletal disorders that are impossible to exercise
• Subjects who are allergic to soybeans, coix, and brown rice