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Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.
Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Resistance training has been shown to improve strength, sleep quality and mobility in persons with MS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Active Comparator | Only testing sessions |
|
| Progressive resistance training group | Experimental | 10-weeks of progressive resistance training group. Leg press, leg extension, calf raises, hip extension exercises. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical exercise | Other | Physical exercise intervention |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal Voluntary Isometric Contraction of Knee Extension | the maximum force (N) that can be produced voluntarily by the knee extension muscles during an isometric contraction is measured. The leg of the participant is fixed to an isokinetic device, and the participant makes a 5-second attempt, developing all the strength he or she can. | Before the program training |
| Maximal Voluntary Isometric Contraction of Knee Extension | the maximum force (N) that can be produced voluntarily by the knee extension muscles during an isometric contraction is measured. The leg of the participant is fixed to an isokinetic device, and the participant makes a 5-second attempt, developing all the strength he or she can. | After 10 weeks |
| Rate of Force Development | Rate of force development in knee extension | Before the program training |
| Rate of Force Development | Rate of force development in knee extension | After 10 weeks |
| Central Activation Ratio | The central activation ratio (CAR) was determined using superimposed electrical stimulation during maximum voluntary contractions | Before the program training |
| Central Activation Ratio | The central activation ratio (CAR) was determined using superimposed electrical stimulation during maximum voluntary contractions | After 10 weeks |
| Spasticity |
| Measure | Description | Time Frame |
|---|---|---|
| Walking speed | Test 10 m-walks | Before the program training |
| Walking speed | Test 10 m-walks | After 10 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jacobo Á Rubio-Arias, Dr | Universidad Politecnica de Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Católica San Antonio | Murcia | 30107 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35905806 | Derived | Andreu-Caravaca L, Ramos-Campo DJ, Chung LH, Rubio-Arias JA. Can strength training modify voluntary activation, contractile properties and spasticity in Multiple Sclerosis?: A randomized controlled trial. Physiol Behav. 2022 Oct 15;255:113932. doi: 10.1016/j.physbeh.2022.113932. Epub 2022 Jul 27. | |
| 34107841 | Derived |
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The data will be published in a journal
After the completion of study
The data will be published in a journal
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| Testing sessions |
| Other |
Testing sessions |
|
Pendulum test |
| Before the program training |
| Spasticity | Pendulum test | After 10 weeks |
| Static Balance | Romberg Test with eyes open and closed. Analysis with force plates | Before the program training |
| Static Balance | Romberg Test with eyes open and closed. Analysis with force plates | After 10 weeks |
| Functional capacity | Sit-to-Stand Test | Before the program training |
| Functional capacity | Sit-to-Stand Test | After 10 weeks |
| Heart Rate Variability | Sleeping Heart Rate Variability | Before the program training |
| Heart Rate Variability | Sleeping Heart Rate Variability | After 10 weeks |
| Sleep Quality | Acelerometry and Karolinska Sleep Diary | Before the program training |
| Sleep Quality | Acelerometry and Karolinska Sleep Diary | After 10 weeks |
| Andreu-Caravaca L, Ramos-Campo DJ, Abellan-Aynes O, Avila-Gandia V, Chung LH, Manonelles P, Rubio-Arias JA. 10-Weeks of resistance training improves sleep quality and cardiac autonomic control in persons with multiple sclerosis. Disabil Rehabil. 2022 Sep;44(18):5241-5249. doi: 10.1080/09638288.2021.1934738. Epub 2021 Jun 9. |
| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D009422 | Nervous System Diseases |
| D007319 | Sleep Initiation and Maintenance Disorders |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D003711 | Demyelinating Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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