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This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.
Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise group | Experimental | Exercise group who performed a combined exercise and 300 kcal/day deficit diet during 12 weeks. |
|
| Control group | Placebo Comparator | Control group who performed 300 kcal/day deficit diet during 12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Combined exercise program | Other | Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet |
| Measure | Description | Time Frame |
|---|---|---|
| body fat percent | Changes in body fat percent during 12 weeks | Change from baseline body fat percent at 12 weeks |
| acylated ghrelin | Changes in concentrations of acylated ghrelin during 12 weeks | Change from concentrations of baseline acylated ghrelin at 12 weeks |
| desacylated ghrelin | Changes in concentrations of desacylated ghrelin during 12 weeks | Change from concentrations of baseline desacylated ghrelin at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| ghrelin O acyl transferase | Changes in concentrations of ghrelin O acyl transferase during 12 weeks | Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sang Yeoup Lee, MD, PhD | Pusan National University Yangsan Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pusan National University Yangsan Hospital | Yangsan | Gyeungsangnam-do | 50612 | South Korea |
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| Control | Other | 300 kcal deficit diet only |
|