Comparison of Postoperative Recovery Between TIVA and Inhalation Agent

Randomized Controlled Trial of the Effect of General Anesthetics on Postoperative Recovery After Minimally Invasive Nephrectomy (REGAIN Trial)

This prospective, randomized, single-blinded study is designed to compare the postoperative quality of recovery between propofol based total intravenous anesthesia and desflurane in patients undergoing minimally invasive nephrectomy. We hypothesize that propofol based total intravenous anesthesia can significantly improve the quality of recovery after surgery in patients with minimally invasive nephrectomy.

Adult patients undergoing elective laparoscopic or robotic assisted nephrectomy are randomly allocated to receive propofol based total intravenous anesthesia (n=75) or desflurane (n=75). The quality of recover after surgery using the QoR-15K was assessed by a investigator at postoperative day (POD) 1, 2, and 3. The primary outcome is the QoR-15K at POD 1, 2, and 3 after surgery.

Inclusion Criteria:

• Patients scheduled to undergo elective laparoscopic or robotic assisted nephrectomy under general anesthesia
• American Society of Anesthesiologists (ASA) physical classification I-II
• Willingness and ability to sign an informed consent document

Exclusion Criteria:

• Do not understand our study
• American Society of Anesthesiologists (ASA) physical classification III or more
• Allergies to anesthetic or analgesic medications
• Chronic pain, chronic analgesic or antidepressant or anticonvulsant use
• Medical or psychological disease that can affect the treatment response
• Patients who receive mechanical ventilation more than 2 hours after surgery