Q10 Preloading Before Cardiac Surgery for Kidney Failure Reduction

Q10 Preloading Before Cardiac Surgery for Kidney Failure Reduction

Coenzyme Q10 (CoQ10) is an essential molecule in human body. It acts as an antioxidant, a co-factor for energy conversion in mitochondria and has anti-inflammatory effects capable of improving endothelial function. Our goal is to investigate whether CoQ10 is capable to reduce the incidence of acute kidney injury/failure following cardiac surgery. Cardiac surgery is major risk factor for acute kidney injury/failure (AKI/F).

Inclusion Criteria:

• Adult patients scheduled for elective cardiac surgery

Exclusion Criteria:

• patients receiving high dose vitamin B supplementation (defined as more that 200% of recommended daily allowances)
• patients under warfarin therapy
• urgent surgery
• end stage kidney disease
• therapy with multiple nephrotoxic drugs
• chronic kidney disease
• obstructive uropathy
• previous cardiac surgery procedure
• alcohol abuse
• malignancy
• allergy to any ingredient of Myoqinon capsule
• patients receiving Myoqinon and fail to demonstrate a significant increase in blood concentration of Q10
• uncontrolled hypertension