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| Name | Class |
|---|---|
| The First Affiliated Hospital with Nanjing Medical University | OTHER |
| Beijing Anzhen Hospital | OTHER |
| West China Hospital | OTHER |
| The First Affiliated Hospital of Guangzhou Medical University |
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Cardiovascular diseases are the leading causes of death and prescription drug use. Research on certain dietary supplements looks promising as a way to help reduce risk factors. Previous studies showed that CoQ10 levels were decreased in cardiovascular patients and worsening of mitochondrial dysfunction was observed. The overall objective of this study is to determine if supplementing with CoQ10 can reduce inflammatory risk factors in adults with cardiac surgery, independent of other dietary or physical activity changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coenzyme Q10 group | Experimental | Participants in the experimental group will be given 10mg of Coenzyme Q10 each time (3 times a day). |
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| Control | Sham Comparator | patients only receive standard medical therapy. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coenzyme Q10 | Drug | Coenzyme Q10 is a cardiovascular health supplement. It is a component of the electron transport chain and participates in aerobic cellular respiration, which generates energy in the form of ATP. The ingredients in Coenzyme Q10 help regulate the body's production of free radicals, strengthen the arteries and heart, and reverse oxidation. |
| Measure | Description | Time Frame |
|---|---|---|
| C-reactive protein | Inflammatory and endothelial blood work biomarkers | Change from baseline of CRP in mg/L at 5 days after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Interleukin-6 | Inflammatory and endothelial blood work biomarkers | Change from baseline of IL-6 in pg/mL at 5 days after surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hong Liu, MD | Contact | 8618801281613 | dr.hongliu@foxmail.com | |
| Yong-feng Shao, MD | Contact | 02568303101 | yfshaojph@sina.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Anzhen Hospital | Recruiting | Beijing | Beijing Municipality | China |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C024989 | coenzyme Q10 |
| D014451 | Ubiquinone |
| ID | Term |
|---|---|
| D016227 | Benzoquinones |
| D011809 | Quinones |
| D009930 | Organic Chemicals |
| D003067 | Coenzymes |
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| OTHER |
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|
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| Standard Medical Therapy | Dietary Supplement | Patients only received standard medical therapy without CoQ10. |
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| The First Affiliated Hospital of Guangzhou Medical University | Recruiting | Guangzhou | Guangdong | China |
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| The First Affiliated Hospital of Nanjing Medical University | Recruiting | Nanjing | Jiangsu | 210029 | China |
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| West China Hospital of Sichuan University | Recruiting | Chengdu | Sichuan | China |
|
| D045762 |
| Enzymes and Coenzymes |