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Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .
Progesterone is an neurosteroid that can help integrity of blood brain barrier . Traumatic subarachinoid hemorrhage disrupts this blood brain barrier facilitating post traumatic vasospasm and neuronal ischemia. Transcranial doppler can detect cerebral vasoconstriction through resistive vasculer indices
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Receiving conventional management for traumatic subarachinoid hemorrhage |
|
| progesterone group | Active Comparator | Intramusculer progesterone therapy before and after craniotomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progesterone | Drug | Intramusculer progesterone |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants suffering neuronal infarction | Transcranial doppler | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
History of malignency
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mina Raouf, MD | Contact | 01015752424 | drmina2015@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hany Mikhail, MD | Faculty of medicine. ElMinia University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ElMinia University | Recruiting | Minya | Abohelal | 6115 | Egypt |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D011374 | Progesterone |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D003339 | Corpus Luteum Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |
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