Cytoprotective Effect and Clinical Outcome of Perioperative Proesterone in Brain Tumors

Cytoprotective Effect and Clinical Outcome of Perioperative Proesterone in Brain Tumors

Neuronal injury is evident in elective craniotomy for space occupying lesions. Surgical trauma and mechanichal impact of the tumor causes neuronal injury. Neurosreroid progesterone is a neurotransmittern , trail to use in abolishing neurotoxcicty

Progesterone is a natural neurosteroid that we are trying to use to impede both direct neuronal injury cauesd by and indirectly by surgical trauma. Progesterone can decreas vasogenic brain oedema. Our primary outcome is to ameliorate microscopic cytoplasmic injury and decrease brain oedema exploited by biopsy from brain tumor interface. Exclusion criteria demonstratd as refusal to participate in the trial , emergency craniotomy, recurrent brain tumor.

Inclusion Criteria:

• All elective brain tumors elligible for craniotomy

Exclusion Criteria:

• Refusal to participare
• Emergency craniotomy