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| Name | Class |
|---|---|
| Hochschule Geisenheim University | UNKNOWN |
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The evidence on the consumption of 100% orange juice in people with type 2 diabetes is highly variable and largely out-of-date, with a few studies reporting acute negative glycaemic effects when 100% orange juice is drunk with or without a meal. The aim of the project is to study the impact of the intake of a single serving of 100% orange juice on glycaemic control in male patients with pre-existing type 2 diabetes mellitus. In addition, immunological parameters and Alzheimer disease related biomarkers will be assessed to examine the chronic inflammatory state of these patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | Other | orange juice concentrate |
|
| Group 2 | Other | Sugar-sweetened orange-flavoured beverage |
|
| Group 3 | Other | Whole orange juice with skin removed |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| orange juice concentrate | Other | 250mL of 100% orange juice made from concentrate |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Glycaemic responses venous blood | Venous blood samples collected to examine systemic glycemia (venous blood glucose concentration (mg/dL)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | baseline |
| Glycaemic responses venous blood | Venous blood samples collected to examine systemic glycemia (venous blood glucose concentration (mg/dL)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Day 5 |
| Glycaemic responses venous blood | Venous blood samples collected to examine systemic glycemia (venous blood glucose concentration (mg/dL)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Day 10 |
| Insulin responses | Venous blood samples collected to examine systemic insulinemia (venous blood insulin concentration (pmol/L)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Baseline |
| Insulin responses | Venous blood samples collected to examine systemic insulinemia (venous blood insulin concentration (pmol/L)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Day 5 |
| Insulin responses | Venous blood samples collected to examine systemic insulinemia (venous blood insulin concentration (pmol/L)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. |
| Measure | Description | Time Frame |
|---|---|---|
| Glycated haemoglobin measure | Measured on a single blood sample to characterize patients' overall glycaemic contro | Baseline |
| Flow cytometry | Fasting venous blood samples collected to examine Peripheral blood mononuclear cells (flow cytometry) to measure immunological parameters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dominique Hansen, prof. dr. | Hasselt University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hasselt University | Hasselt | 3500 | Belgium |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Sugar-sweetened orange-flavoured beverage |
| Other |
Sugar-sweetened orange-flavoured beverage, energy-matched to the orange juice condition |
|
| Whole orange juice with skin removed | Other | Whole orange pieces with skin removed, energy-matched to the orange juice condition |
|
| Day 10 |
| Capillary glycaemic responses | Capillary blood samples collected to examine glycemia before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Baseline |
| Capillary glycaemic responses | Capillary blood samples collected to examine glycemia before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Day 5 |
| Capillary glycaemic responses | Capillary blood samples collected to examine glycemia before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial. | Day 10 |
| Baseline |
| Alzheimer disease related biomarkers | Blood samples will be collected every 30 min for 5 hours to examine Alzheimer disease relevant biomarkers (Abeta42, Abeta40, Tau, p-Tau, neuroinflammatory markers and other) | Baseline |
| BMI | body weight/height (to determine BMI) | Baseline |
| Waist/hip circumference (Body composition) | Waist/hip circumference | Baseline |
| Systolic/diastolic blood pressure | Systolic/diastolic blood pressure | Baseline |
| D004700 | Endocrine System Diseases |