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Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.
Healthy volunteers will consume orange juice with added water or food-grade hesperidin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control meal | Placebo Comparator | glucose, fructose, sucrose, malic acid and citric acid in water |
|
| test meal 1 | Experimental | orange juice with added hesperidin (low dose) |
|
| test meal 2 | Experimental | orange juice with added hesperidin (high dose) |
|
| test meal 3 | Experimental | diluted orange juice with added hesperidin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| control | Other | balancing sugars and organic acids |
| |
| test meal 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose concentration | iAUC/[glucose]max | 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Leeds | Leeds | LS29JT | United Kingdom |
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| Other |
orange juice plus hesperidin low dose |
|
| test meal 2 | Other | orange juice plus hesperidin higher dose |
|
| test meal 3 | Other | diluted orange juice plus hesperidin low dose |
|