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This study is performed to investigate the effect of opioid-free general anesthesia on the recovery quality after gynecological laparoscopy.
The quality of recovery after the surgery is assessed using the QoR 40. In addition, the various kinds of cytokine are assessed for the ancillary study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| opioid-free anesthesia | Experimental | The study group receives the dexmedetomidine and lidocaine infusion with general anesthesia for gynecological laparoscopy. |
|
| opioid anesthesia | Active Comparator | The control group receives the remifentanil infusion with general anesthesia for gynecological laparoscopy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine Hydrochloride | Drug | dexmedetomidine iv bolus followed by the infusion of 0.1-1 ug/kg/hr during general anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| the quality of recovery | The quality of recovery is assessed using questionnaire. This questionnaire includes 40 items. The score range is from 40 to 200. The higher score means the better quality of recovery after surgery. | at 24 hour after the completion of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| cytokine | as ancillary study, to assess the various kinds of cytokines such as epinephrine, norepinephrine, interleukin-10, tumor necrosis factor-alpha. | during surgery |
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Inclusion Criteria:
Exclusion Criteria:
the patients undergoing the gynecological laparoscopic surgery
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| Name | Affiliation | Role |
|---|---|---|
| Youngeun Moon, MD | Seoul St. Mary's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St.Mary's Hospital | Seoul | Seocho-gu | 06591 | South Korea | ||
| Seoul St.Mary's Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33712080 | Derived | Song JY, Choi H, Chae M, Ko J, Moon YE. The effect of opioid-free anesthesia on the quality of recovery after gynecological laparoscopy: study protocol for a prospective randomized controlled trial. Trials. 2021 Mar 12;22(1):207. doi: 10.1186/s13063-021-05166-z. |
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| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| ID | Term |
|---|---|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D008012 | Lidocaine |
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Lidocaine Hydrochloride | Drug | lidocaine iv bolus followed by the infusion of 1.5 mg/kg/hr during general anesthesia |
|
|
| Remifentanil Hydrochloride | Drug | remifentanil iv infusion of 0.5-5 ng/ml (effect site concentration using TCI) during general anesthesia |
|
|
| Seoul |
| Seocho-gu |
| 07651 |
| South Korea |
| D000083 |
| Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D010880 | Piperidines |