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The aim of this study is to evaluate the amniotic fluid and serum progesterone level and pregnancy outcome
Studies have investigated the relationship between maternal serum progesterone level and low birth weight baby birth, hypertensive disorders of pregnancy, and early pregnancy bleeding. In some cases, patients are supported by oral or vaginal progesterone treatments during pregnancy. We also measure the relationship between maternal serum progesterone by measuring the level of amnion progesterone; We aimed to analyze the effects on pregnancy outcomes by observing preterm birth, premature rupture of membranes, low birth weight, baby gender, maternal problems that may occur during pregnancy, fetal problems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | amniotic fluid progesterone (this group will be evaluated by the amniotic fluid which was received via amniocentesis). This group consisted of pregnant women who had high risk in the antenal test and give consent to perform amniocentesis. Notwithstanding, amniocentesis detects chromosome abnormalities, neural tube defects, and genetic disorders for the fetuses. İn a routine amniocentesis, 1-2 ml amniotic fluid which was taken in the first place was discarded in order to prevent maternal contamination. Then 15-20 ml amniotic fluid was taken from all of the patients to diagnose genetic disorders of the fetuses. İn this study we evaluate the amniotic fluid progesterone in this 1-2 ml amniotic fluid which was discarded and throw away. Therefore, we are not performing an extra invasive procedure for pregnant women |
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| 2 | serum progesterone (this group consisted of the pregnant women who have amniocentesis procedure and blood samples were taken in the same procedure ) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| amniocentesis | Diagnostic Test | amniocentesis will be performed to the pregnant women at 16-20 weeks who had a high-risk antenatal test. Furthermore, these women also give a blood sample (at 16-20 weeks) to compare the amniotic fluid and serum progesterone levels in association with pregnancy outcomes. We perform amniocentesis to evaluate genetic disorders in pregnant women who had his risk in the antenal test. |
| Measure | Description | Time Frame |
|---|---|---|
| pregnancy outcome | premature membran rupture Web sonuçları Premature Rupture of Membranes | starting from 16 weeks, ending at the delivery of the baby |
| pregnancy outcome | pregnancy loss | starting from 16 weeks, ending at the delivery of the baby |
| pregnancy outcome | preeclampsia | starting from 16 weeks, ending at the delivery of the baby |
| pregnancy outcome | gestational diabetes | starting from 16 weeks, ending at the delivery of the baby |
| Measure | Description | Time Frame |
|---|---|---|
| fetal outcomes | low birth weight | starting from 16 weeks, ending at the delivery of the baby |
| fetal outcomes | preterm labor | starting from 16 weeks, ending at the delivery of the baby |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of 18-45 years old pregnant women who had a high risk in the antenatal screening test and give consent to perform amniocentesis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| tufan arslanca, M.D. | Contact | +905324580546 | drtufanarslanca@hotmail.com | |
| banu arslanca, M.D. | Contact | +90 532 253 80 13 | dr.banubozkurt@hotmail.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 5157500 | Result | Johansson ED, Jonasson LE. Progesterone levels in amniotic fluid and plasma from women. I. Levels during normal pregnancy. Acta Obstet Gynecol Scand. 1971;50(4):339-43. doi: 10.3109/00016347109157335. No abstract available. | |
| 7072456 | Result | Lau IF, Saksena SK, Salmonsen R. The concentration of progesterone, 20 alpha-dihydroprogesterone, testosterone, oestrone and oestradiol-17 beta in serum, amniotic fluid and placental tissue of pregnant rabbits. Acta Endocrinol (Copenh). 1982 Apr;99(4):605-11. doi: 10.1530/acta.0.0990605. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| ID | Term |
|---|---|
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D000649 | Amniocentesis |
| ID | Term |
|---|---|
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| fetal outcomes | fetal gender | starting from 16 weeks, ending at the delivery of the baby |
| Related Info | View source |
| D003933 | Diagnosis |
| D019152 | Paracentesis |
| D013048 | Specimen Handling |
| D011296 | Prenatal Diagnosis |
| D003944 | Diagnostic Techniques, Obstetrical and Gynecological |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |