Prognostic Value of Progesterone for In Vitro Fertilization (IVF) Outcome

The Effect of Serum Progesterone Levels on the Day of hCG Administration on the Probability of Pregnancy in Patients Treated by IVF Using GnRH Antagonists and Recombinant Gonadotrophins

This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins.

There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF.

This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.

Inclusion Criteria:

• Age < 40 years
• Basal FSH < 12 IU/L
• Basal P < 1.6 ng/mL

Exclusion Criteria:

• Presence of cystic formations at the ovaries during the basal ultrasound scan (prior the initiation of stimulation)
• Women with polycystic ovaries syndrome (PCOS)
• Women with Stage III-IV Endometriosis
• Women with a pathological condition of the adrenal glands