Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy

Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study

Hypotheses:

We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.

Aims:

To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT).

Primary outcome:

To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer

Secondary outcomes:

Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.

Inclusion Criteria:

• Patients undergoing FET cycles
• Infertility patients aged >18 years old and < 42 years old
• BMI < 30 kg/m2
• Transfer of at least one good-quality embryo.

Exclusion Criteria:

• Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
• Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)