Progesterone Rise in Agonist Versus Antagonist in Vitro Fertilization (IVF) Cycles

Is the Clinical Outcome Affected by the Incidence of Progesterone Elevation on the Day of hCG Triggering When Agonist Protocol is Compared to Antagonist Protocol for IVF

The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy achievement.

In view of the current debate concerning possible differences in efficacy between the two GnRH analogues, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH-agonist is used as compared to GnRH-antagonist and if so to what extend does the progesterone rise have an impact on the probability of achieving a pregnancy.

Inclusion Criteria:

• age < 39
• follicle-stimulating hormone (FSH) < 12
• gonadotropin dose 100-300IU

Exclusion Criteria:

• endometriosis
• known endocrine disorder
• blood analyzed in another laboratory