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| Name | Class |
|---|---|
| BioGenesis | INDUSTRY |
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The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy achievement.
In view of the current debate concerning possible differences in efficacy between the two GnRH analogues, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH-agonist is used as compared to GnRH-antagonist and if so to what extend does the progesterone rise have an impact on the probability of achieving a pregnancy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Antagonist group | Experimental | Antagonist protocol for IVF |
|
| Agonist group | Active Comparator | Long Agonist protocol for IVF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| In vitro fertilization | Other | In vitro fertilization procedure with gonadotropin induced follicular ovarian stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of late progesterone rise on the day of HCG triggering | Up to delivery (2010) |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate Delivery rate | Up to delivery (2010) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Basil Tarlatzis, MD | BioGenesis | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Biogenesis | Thessaloniki | Pylaia | 55536 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17555751 | Background | Papanikolaou EG, Kolibianakis EM, Pozzobon C, Tank P, Tournaye H, Bourgain C, Van Steirteghem A, Devroey P. Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer. Fertil Steril. 2009 Mar;91(3):949-52. doi: 10.1016/j.fertnstert.2006.12.064. Epub 2007 Jun 6. | |
| 22422777 |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D005307 | Fertilization in Vitro |
| D011247 | Pregnancy |
| D004624 | Embryo Transfer |
| D011374 | Progesterone |
| ID | Term |
|---|---|
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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|
| Derived |
| Papanikolaou EG, Pados G, Grimbizis G, Bili E, Kyriazi L, Polyzos NP, Humaidan P, Tournaye H, Tarlatzis B. GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Hum Reprod. 2012 Jun;27(6):1822-8. doi: 10.1093/humrep/des066. Epub 2012 Mar 14. |
| D012098 | Reproduction |
| D055703 | Reproductive Physiological Phenomena |
| D012101 | Reproductive and Urinary Physiological Phenomena |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D003339 | Corpus Luteum Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |