Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist

The Effect of the Type of Ovarian Stimulation Protocol on PGD Results: a Prospective Randomised Trial

The aim of our study is to define the optimal ovarian stimulation protocol concerning PGD and for this reason we plan a randomized controlled trial (RCT) comparing gonadotropin-releasing hormone (GnRH) agonist protocol versus GnRH antagonist protocol. The follicle stimulating hormone (FSH) preparation in both arms will be highly purified FSH (Menopur®).

Patients will be randomized at the outpatient clinic in two groups.

Inclusion Criteria:

• ≤ 39 years the day of oocyte retrieval
• BMI ≤ 29
• cycle rank 1
• menstrual cycle 25-36 days
• PGD or preimplantation genetic screening (PGS) requested
• ICSI
• Single embryo transfer (SET) on day 5

Exclusion Criteria:

• Polycystic Ovary Syndrome (PCOS) (according Rotterdam criteria)
• Hormonal disturbances
• Endometriosis grade III and IV