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This study was conducted to investigate the effects of daily supplementation of Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures on the Improvement of Blood Flow.
This study was a 12-week, randomized, double-blind, placebo-controlled human trial. 80 subjects were randomly divided into Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures group and a placebo group. It is to evaluate the changes in the displayed evaluation items when taking Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures once a day, in comparison with taking a placebo.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Improvement of Blood Flow group | Experimental | One packet once a day, after breakfast (1.5 g/day, 1.5 g/day as an Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures) |
|
| Placebo group | Placebo Comparator | One packet once a day, after breakfast (1.5 g/day) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures | Dietary Supplement | One packet once a day, after breakfast, for 12 week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Platelet function assay(PFA) | The concentration of Platelet function assay(PFA) was assessed before and after the intervention | Baseline, 12 week |
| Changes of blood viscosity | The concentration of blood viscosity was assessed before and after the intervention | Baseline, 12 week |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of systolic blood pressure(SBP), diastolic blood pressure(DBP), Pulse | systolic blood pressure(SBP), diastolic blood pressure(DBP), Pulse were measured in study screening, visit 1(0 week), visit 2(6 weeks) and visit 3(12 weeks). | screening, 0 week, 6 week, 12 week |
| Changes of blood coagulation-related indices |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Soo Wan Chae, Ph.D., M.D. | Contact | 82-63-259-3040 | soowan@jbnu.ac.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Trial Center for Functional Foods Chonbuk National University Hospital | Recruiting | Jeonju | Jeollabuk-do | 54907 | South Korea |
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| Placebo | Dietary Supplement | Placebo for 12 week |
|
Blood coagulation-related indices(e.g. Plasminogen activator inhibitor-1, Serotonin, Thromboxane B2, activated partial thromboplastin time) were measured in study visit 1(0 week) and visit 3(12 weeks). |
| Baseline, 12 week |
| Changes of indicator of lipid metabolism | Lipid metabolism(e.g. Total cholesterol, Triglyceride, Low Density Lipoprotein-cholesterol, High Density Lipoprotein-cholesterol, Non High Density Lipoprotein-cholesterol) was measured in study visit 1(0 week) and visit 3(12 weeks). | Baseline, 12 week |
| Changes of atherosclerosis index | Atherosclerosis index(e.g. Total cholesterol/High Density Lipoprotein-cholesterol, Low Density Lipoprotein-cholesterol/High Density Lipoprotein-cholesterol, Triglyceride/High Density Lipoprotein-cholesterol, (Total cholesterol-High Density Lipoprotein-cholesterol)/High Density Lipoprotein-cholesterol) was measured in study visit 1(0 week) and visit 3(12 weeks). | Baseline, 12 week |