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Epilepsy is one of the most common chronic neurological conditions.It leads to cognitive impairment in 20-50% of patients with a structural form.
In comparison with seizures, these cognitive disorders are a major additional factor in occupational, social and family disability. They are particularly frequent (50%) in temporal epilepsies and preferably concern memory and language skills.
The cognitive consequences of epilepsy are therefore well described in the following areas: episodic memory, language, executive functions.
Concerning attentional abilities, a recent review has highlighted the lack of work in this specific field in order to properly measure the prevalence and nature of attentional disorders in epileptic patients. Indeed, attentional abilities are often mentioned in studies, but attention is a complex domain defined by four modalities: alertness, selective attention, divided attention and sustained attention. No study systematically assesses all of these modalities.
The objective of this study is to evaluate the prevalence and nature of attentional disorders in epileptic patients compared to control subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with epilepsy | Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale) |
| |
| Normal controls | Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Attentional tasks | Other | a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control |
|
| Measure | Description | Time Frame |
|---|---|---|
| d2-r | selective attention task | 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| sustained attention TAP Subtest | Your task is to press the key as quickly as possible whenever two successive patterns have the same shape | 15 minutes |
| alertness attention TAP Subtest | a cross appears on the screen. press the key when the cross appears |
| Measure | Description | Time Frame |
|---|---|---|
| digit span | immediate memory task | 5 minutes |
| verbal fluency | executive task | 5 minutes |
Patients:
Inclusion Criteria:
Normal controls:
Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.
Exclusion Criteria:
for patients: with another progressive neurological condition for all People of full age who are subject to a legal protection measure or who are unable to express their consent People deprived of their liberty by a judicial or administrative decision People who regularly use psychoactive substances (cannabis, alcohol...)
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people with epilepsy versus normal control
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| helene BRISSART, Dr | Contact | 383851689 | +33 | h.brissart@chru-nancy.fr |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30826090 | Result | Brissart H, Forthoffer N, Maillard L. Attention disorders in adults with epilepsy. Determinants and therapeutic strategies. Rev Neurol (Paris). 2019 Mar;175(3):135-140. doi: 10.1016/j.neurol.2019.01.394. Epub 2019 Feb 28. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Apr 2, 2020 | May 6, 2020 | Prot_000.pdf |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| 8 minutes |
| divided attention TAP Subtest | first task :a cross appears on the screen in which a varying number of crosses appear simultaneously. when four of these crosses form a square, then please press the key as quickly as possible. second task: in this task you will hear a high and a low tone in sequence. you must decide whether the same tone occurs twice in a row. Please press the key as quickly as possible. | 5 minutes |
| incompatibility TAP subtest | executive task | 8 minutes |
| flexibility TAP subtest | executive task | 8 minutes |
| Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) | Depression scale score 0 to 24 | 3 minutes |
| GENERALIZED ANXIETY DISORDER (GAD-7) | ANXIETY scale score : 0 to 21 | 3 minutes |