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Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| All included subjects | Other | Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure. |
| Measure | Description | Time Frame |
|---|---|---|
| Subtest of divided attention of the Test of Attentional Performance (TAP) | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| N200 amplitude and latency | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. | 24 hours |
| Strength of EEG functionnal connectivity during an attentional task (global and regional) |
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Inclusion Criteria:
Exclusion Criteria:
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Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital, | Recruiting | Lille | 59000 | France |
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| ID | Term |
|---|---|
| D004833 | Epilepsy, Temporal Lobe |
| D017034 | Epilepsy, Frontal Lobe |
| D004828 | Epilepsies, Partial |
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
| 24 hours |
| Variation of power in several frequency bands (theta, alpha and beta) during an attentional task. | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. | 24 hours |
| Magnetic resonance imaging functional connectivity. | up to 5 days |
| Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus. | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. | 24 hours |
| P300 amplitude and latency | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. | 24 hours |
| Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus. | 24 hours |
| Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus. | 24 hours |
| Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus. | 24 hours |
| D000073376 |
| Epileptic Syndromes |