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| Name | Class |
|---|---|
| Hospital Universitario 12 de Octubre | OTHER |
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The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
Healthy volunteers are recruited to participate in a parallel study (n 30 per group) for 10 to 12 weeks. Markers of cardiovascular health (FMD, markers of inflammation and fatty acid metabolism) and cognition (neuropsychological tests and plasma neurotrophins) are being measured before and after intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cocoa Flavanols | Active Comparator | Cocoa is taken every day for 10-12 weeks. |
|
| Berries anthocyanins | Active Comparator | Red-berries are taken every day for 10-12 weeks. |
|
| Cocoa flavanols plus berries anthocyanins | Active Comparator | Cooa and red-berries are taken every day for 10-12 weeks. |
|
| Control | No Intervention | Normal diet for 10-12 weeks |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cocoa flavanols and berries anthocyanins | Other | Effect of cocoa flavanols and berries anthocyanins on cardiovascular and cognitive health |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of flow-mediated vasodilatation (FMD) of the brachial artery | The FMD of the brachial artery will be measured using an ultrasound collected at baseline and continuously for 60 seconds post-arm occlusion for 5 minutes. FMD will be expressed as percentage of variation between pre-and postischemic diameters | Over 6 minutes on day 0 and after10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline STROOP score after 10 weeks intervention | STROOP tests attention and executive function. This test aims to evaluate the inhibition of an automated process such as reading by asking participants to name the color of color names written in a different color ink. For each participant SROOP results at inclusion will be compared with results after 10 weeks intervention | at inclusion and 10 weeks after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CISC) | Madrid | 28040 | Spain |
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| Change from baseline Tower of London score after 10 weeks intervention | Tower of London test consist of a three color game board that allows executive functioning evaluation by total time, time to first move and optimal moves change from participants inclusion to week 11. | at inclusion and 10 weeks after intervention |