The Vascular and Cognitive Effects of Chronic High-flavanol Intake in Healthy Males

The Vascular and Cognitive Effects of Chronic High-flavanol Intake in Healthy Males

A randomised, placebo-controlled, parallel human dietary intervention trial conducted in 33 healthy males to investigate the vascular and cognitive effects of bi-daily consumption of high-flavanol (epicatechin-rich) milk chocolate over a 2-week intervention period. Subjects visited the Hugh Sinclair Unit of Human Nutrition on 3 separate occasions; at the beginning, end and post-intervention.

Inclusion Criteria

• Body Mass Index 18.5-27.5 kg/m2
• Normal Blood pressure (< 150/90)
• Non-smoker
• Regular exercise routine
• Signed consent form

Exclusion Criteria:

• Haemoglobin (anaemia marker) < 125 g/l
• Gamma GT (liver enzymes) > 80 IU/l
• Total Cholesterol > 6.5 mmol/l
• Suffered a myocardial infarction or stroke in the last 12 months
• Suffers from any cardiovascular or metabolic disorders
• Suffers from any blood-clotting disorder, and/or takes supporting medication
• Any dietary restrictions or on a weight reducing diet
• On any lipid-modifying or blood pressure lowering medication
• Consuming any specific vitamin/ herbal supplements or fish oils