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The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Fermented Prunus Mume Vinega on Improvement of Fatigue in adults for 8 weeks.
Previous studies have indicated that Fermented Prunus Mume Vinega may have the ability to improve fatigue. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of tFermented Prunus Mume Vinega on Improvement of Fatigue in adults; the safety of the compound are also evaluate. The Investigators examine fatigue severity scale, lactate, creatinine kinase, urinary malondialdehyde at baseline, as well as after 4 and 8 weeks of intervention. Sixty adults were administered either 600 mg of Fermented Prunus Mume Vinega or a placebo each day for 8 weeks;
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fermented Prunus Mume Vinegar group | Experimental | This group takes Fermented Prunus Mume Vinegar for 8 weeks. |
|
| Placebo group | Placebo Comparator | This group takes placebo for 8 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fermented Prunus Mume Vinegar group | Dietary Supplement | This group takes Fermented Prunus Mume Vinegar for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fatigue severity scale | Fatigue severity scale, minimum~maximum values (1~7), higher scores mean a worse outcome. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Lactate level | Lactate level (mg/dL) | 8 weeks |
| Creatinine kinase level | Creatinine kinase level (IU/L) | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sang Yeoup Lee | Pusan National University Yangsan Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pusan National University Yangsan Hospital | Yangsan | Gyeungsangnam-do | 50612 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36438753 | Derived | Choi JI, Lee YL, Lee SY. Efficacy and safety of fermented Prunus mume vinegar on fatigue improvement in adults with unexplained fatigue: A randomized controlled trial. Front Nutr. 2022 Nov 9;9:990418. doi: 10.3389/fnut.2022.990418. eCollection 2022. |
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| ID | Term |
|---|---|
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Placebo group | Dietary Supplement | This group takes placebo for 8 weeks. |
|
| Urinary malondialdehyde level | Urinary malondialdehyde level (mmol/mg Cr) | 8 weeks |