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Rehydration during and after physical exercise is essential to avoid acute kidney injury.
Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.
30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.
Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: glucose - fructose - xylitol - saccharose | Active Comparator |
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| Experimental: fructose - glucose - saccharose - xylitol | Active Comparator |
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| Experimental: xylitol - saccharose - glucose - fructose | Active Comparator |
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| Experimental: saccharose - xylitol - fructose - glucose | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fructose/glucose/xylitol/saccharose | Dietary Supplement |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise | after 60-90 min of pysical exercise | |
| Changes in fractional uric acid excretion | after 60-90 min of pysical exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wojciech Wolyniec, MD,PhD | Contact | 48 600942998 | wolyniecwojtek@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Marcin Renke, prof | Medical University of Gdansk | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Gdansk | Recruiting | Gdansk | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36338481 | Derived | Wolyniec W, Szwarc A, Kasprowicz K, Zorena K, Jaskulak M, Renke M, Naczyk M, Ratkowski W. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol. 2022 Oct 20;13:841056. doi: 10.3389/fphys.2022.841056. eCollection 2022. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D000419 | Albuminuria |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D005632 | Fructose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D007661 |
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|
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D011507 | Proteinuria |
| D014555 | Urination Disorders |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Ketoses |