The Effect of Manipulating Hydration Status During Cycling in the Heat on Acute Kidney Injury Biomarkers

The Effect of Hypohydration During Cycling in the Heat on Acute Kidney Injury Biomarkers

Acute Kidney Injury (AKI) is common in prolonged endurance events. Risk factors for exercise-associated AKI include: the exercise itself, heat, hypohydration, muscle breakdown and non-steroidal anti-inflammatory drug (NSAID) use. Prior research from our laboratory showed the hypohydration during high-intensity running increased a biomarker of AKI (urine osmolality-corrected kidney injury molecule 1). Therefore, the current study will now investigate the effect of manipulating hydration status during cycling on biomarkers of AKI.

Inclusion Criteria:

• Healthy
• recreationally active

Exclusion Criteria:

• Smoker/vaper
• regular use of anti-inflammatory medications (e.g. ibuprofen)
• history of kidney disease or diabetes