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This study will give important information about long term consequences of temporal lobe epilepsy surgery on cognition (memory, language, concentration etc), psychiatric function and quality of life.
All patients in Norway who have undergone temporal lobe epilepsy surgery ten years ago or more, will be invited to participate. Two groups will be compared: patients who are younger than 50 years of age vs patients who are older than 50 years of age.
The aim of the study is to improve preoperative information to future epilepsy surgery patients, to aid medical personnel (doctors, psychologists) in the selection of patients for surgery, and to improve knowledge of need for long term follow-up and rehabilitation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Younger than 50 years of age | Patients who have undergone epilepsy surgery ten years ago or longer, and are currently less than 50 years of age |
| |
| 50 years of age or older | Patients who have undergone epilepsy surgery ten years ago or longer, and are currently 50 years of age or more |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological examination | Other | Neuropsychological follow-up examination, including questionaires |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in each study group on neuropsychological tests of memory from baseline (preoperative) to current evaluation | Memory will be measured by Rey Auditory Verbal Learning Test, results reported as raw scores from 1-worst to 15-best; and Diagnosticum für Cerebralschädugung-Revised - DCS-R, results reported as raw scores from 1-worst to 15-best. All results will be converted to T-scores with average 50, standard deviation 10. | During single data collection session, aproximately 2 hours |
| Change in each study group on neuropsychological tests of language from baseline (preoperative) to current evaluation | Language will be measured by the subtest "Similarities" from Wechsler Adult Intelligence Scale - WAIS-III, results reported as raw scores from 1-worst to 33-best; Boston Naming Test-results reported as raw scores from 1-worst to 60-best; Letter Fluency from Delis Kaplan Executive Function Scale-D-KEFS, raw scores from 1-worst and up. All results will be converted to T-scores. | During single data collection session, aproximately 2 hours |
| Change in each study group on neuropsychological tests of visuospatial abilities from baseline (preoperative) to current evaluation | Visuospatial abilities will be measured by the subtest "Block Design" from WAIS-III, raw scores from 1-worst to 68-best. Results will be converted to T-scores. | During single data collection session, aproximately 2 hours |
| Change in each study group on neuropsychological tests of executive function from baseline (preoperative) to current evaluation | Executive function will be measured by the subtest "Digit Span" from WAIS-III, raw scores from 1-worst, to 30-best; Trails A and B from Halstead test battery, raw scores from 1-worst and up. All results will be converted to T-scores. | During single data collection session, aproximately 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Score on depression questionaire | Beck Depression Inventory (raw scores divided in 4 categories: 0-13 minimal depression, 14-19 mild depression, 20-28 moderate depression and 29-63 serious depression). | During single data collection session, aproximately 2 hours |
| Score on anxiety questionaire |
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Inclusion Criteria:
Exclusion Criteria:
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All patients in Norway who have undergone temporal lobe epilepsy surgery ten years ago or more (all of these have also had a preoperative evaluation, including neuropsychological assessment), and who were 20 years of age or older at the time of surgery
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| Name | Affiliation | Role |
|---|---|---|
| Eli B Kyte, Cand.psych | OUS - SSE | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital, Spesialsykehuset for epilepsi | Oslo | 4950 Nydalen | Norway |
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| ID | Term |
|---|---|
| D004833 | Epilepsy, Temporal Lobe |
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
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|
Beck Anxiety Inventory (raw scores divided in 4 categories: 0-7 minimal anxiety, 8-15 mild anxiety, 16-25 moderate anxiety and 26-63 serious anxiety). |
| During single data collection session, aproximately 2 hours |
| Score on quality of life inventory | Quality of Life in Epilepsy - QUOLIE 89 - results will be reported as overall score ranging from 26-worst, to 95-best, and converted to T-score with average 50, standard deviation 10) | During single data collection session, aproximately 2 hours |
| D000073376 | Epileptic Syndromes |
| D008919 | Investigative Techniques |