Intranasal Dexmedetomidine Versus Intranasal Midazolam for Emergence Delirium Prevention

Comparison of Efficacy of Premedication Between Dexmedetomidine and Midazolam Intranasal for the Prevention of Emergence Delirium in Children Undergoing Ophthalmic Surgery

This study is a double-blind clinical trial, in pediatric patients aged 1-12 years with physical status ASA (American Society of Anesthesiology) 1 and 2 who underwent eye surgery under general anesthesia using Sevoflurane inhalation agents, in investigator institution during February-May 2019.. There were 64 children obtained by consecutive sampling, who underwent eye surgery in investigator institution during February-May 2019. The subjects then grouped into dexmedetomidine group and midazolam group. Effectiveness was assessed from Emergence Delirium (ED) events, recovery time, and post-premedication desaturation events. Data analysis using Chi Square test and Mann-Whitney test.

There were 64 children obtained by consecutive sampling, The subjects then grouped into dexmedetomidine group and midazolam group. Effectiveness was assessed from ED events, recovery time, and post-premedication desaturation events.

Inclusion Criteria:

• children undergoing ophthalmologic surgery with general anesthesia
• children aged 1 - 12 years old
• physical status ASA 1-2
• signing informed consent

Exclusion Criteria:

• children undergoing emergency surgery
• children with PICU nursing after surgery
• children with psychological and neurological condition
• children with allergic history to dexmedetomidine and midazolam
• children with history of malignant hyperthermia or family history of malignant hyperthermia
• children with possibility of difficult intubation and ventilation