Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children

Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children: Superiority Randomized Clinical Trial

Study where children will receive one premedication, either intranasal dexmedetomidine or oral midazolam, to reduce agitation on emergence of anesthesia. The hypothesis is that dexmedetomidine is superior but previous studies lack quality.

Children will be randomized to receive, either midazolam (0.5mg/kg) or dexmedetomidine (1mcg/kg), as anesthetic premedication. Emergence agitation will be assessed by PAED scale.

Inclusion Criteria:

• Scheduled for amygdalectomy
• American Society of Anesthesiologists Physical Status PI or PII
• Absence of congenital neuropathy
• Absence of cardiac pathology (any)
• Intolerance to one of the studied drugs.

Exclusion Criteria:

• Protocol violation
• Need to transfer for ICU intubated