The proposed study will examine brain mechanisms of a brief mindfulness intervention - integrative body-mind training (IBMT) on alcohol, tobacco, and cannabis (ATC) reduction.

The R61 phase of the proposed study will examine brain mechanisms of a brief mindfulness intervention - integrative body-mind training (IBMT) that targets at self-control networks in the brain, and test IBMT effects on alcohol, tobacco, and cannabis (ATC) reduction.

Inclusion Criteria:

• (1) at least 18 years old;
• (2) free of any psychiatric diagnoses or medication (besides a substance use disorder to alcohol, tobacco, or cannabis);
• (3) in the past month, at least 4 episode of heavy episodic drinking; at least 3 occasion of cannabis use; and daily cigarette use for at least the past month;
• (4) normal or corrected-to-normal vision;
• (5) written informed consent;
• (6) no previous meditation or neurofeedback (NF) experiences.

Exclusion Criteria:

• (1) any psychiatric diagnoses other than a substance use disorder;
• (2) medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females);
• (3) excluding cannabis, evidence of recent (past month) illicit drug use.

6 months