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| Name | Class |
|---|---|
| Lotte und Adolf Hotz-Sprenger Stiftung | UNKNOWN |
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Patients with long-term lower urinary tract dysfunction due to spinal cord injury presenting for a routine urodynamic control will be screened for inclusion and exclusion criteria. Suitable individuals providing written informed consent will undergo renal Doppler sonography and renal scintigraphy in addition to the routine examinations. Conclusions regarding renal function based on the clearance rate determined by scintigraphy (gold standard) will be compared with the conclusions based on Doppler sonography and Cystatin C clearance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal renal function | individuals with renal clearance >89 ml/min/1.73m² |
| |
| mild renal insufficiency | individuals with renal clearance 60-89 ml/min/1.73m² |
| |
| moderate renal insufficiency | individuals with renal clearance 30-59 ml/min/1.73m² |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| renal scintigraphy | Diagnostic Test | Technetium-99m-dimercaptosuccinic acid scintigraphy of both kidneys |
|
| Measure | Description | Time Frame |
|---|---|---|
| renal clearance | renal clearance of Technetium-99m-dimercaptosuccinic acid determined by scintigraphy | at the time of inclusion into study |
| Measure | Description | Time Frame |
|---|---|---|
| Cystatin C concentration | blood serum concentration of Cystatin C (mg/L) | at the time of inclusion into study |
| Cystatin C clearance | renal clearance of Cystatin C (ml/min) according to the Grubb formula |
| Measure | Description | Time Frame |
|---|---|---|
| size of kidneys | size of kidneys evaluated by sonography | at the time of inclusion into study |
| renal tissue echogenicity | renal tissue echogenicity evaluated by sonography |
Inclusion Criteria:
Exclusion Criteria:
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individuals with long-term lower urinary tract dysfunction due to spinal cord injury
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| Name | Affiliation | Role |
|---|---|---|
| Jens Wöllner, Dr. | Swiss Paraplegic Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Swiss Paraplegic Centre | Nottwil | Canton of Lucerne | CH-6207 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41396487 | Derived | Jehli E, Krebs J, Schirp U, Walter MA, Wollner J, Pannek J. Decoding kidney function: evaluating arterial resistive index and cystatin C serum values in individuals with spinal cord injury. World J Urol. 2025 Dec 15;44(1):43. doi: 10.1007/s00345-025-06135-w. |
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data will be made available upon reasonable request
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D051437 | Renal Insufficiency |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| renal doppler sonography | Diagnostic Test | doppler ultrasound of both kidneys |
|
| at the time of inclusion into study |
| renal peak systolic velocity | Doppler sonography evaluation of renal blood flow during systolic heart phase (m/s) | at the time of inclusion into study |
| renal peak enddiastolic velocity | Doppler sonography evaluation of renal blood flow during enddiastolic heart phase (m/s) | at the time of inclusion into study |
| renal resistive index | (systolic velocity - enddiastolic velocity) / systolic velocity | at the time of inclusion into study |
| at the time of inclusion into study |
| bladder evacuation method | method of bladder evacuation | at the time of inclusion into study |
| lesion level | highest intact spinal cord segment | 1 year after spinal cord injury |
| lesion severity | severity of spinal cord injury according to American Spinal Injury Association Impairment Score (AIS) (A = motor and sensory complete, B = motor complete and sensory incomplete, C & D = motor and sensory incomplete, E = motor and sensory intact) | 1 year after spinal cord injury |
| duration of spinal cord injury | time from spinal cord injury to inclusion into study (years) | at the time of inclusion into study |
| age | time from birth to inclusion into study (years) | at the time of inclusion into study |
| D014947 | Wounds and Injuries |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |