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The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract infections in patients suffering from chronic (> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization.
The following hypotheses will be tested:
To investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract infections in patients suffering from chronic (> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization, patients perform self-catheterization twice (before and after urodynamic testing. After each catheterization, residual urine is assessed by ultrasound. Prior to urodynamic testing, prostate massage is performed, bacterial cultures of the fluid and the urine are initiated and the results of these cultures will be analysed .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| urinary tract infection | urinary tract infection in male patients with neurogenic bladder dysfunction due to spinal cord injury managed by intermittent catheterization |
| |
| control group | less than three urinary tract infections / year |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sonographic assessment of residual urine, urine culture | Other | residual urinary volume assessed by ultrasound after bladder catheterization urinary cultures taken before and after prostate massage |
| Measure | Description | Time Frame |
|---|---|---|
| amount of residual urine | determined by ultrasound | change from self-catheterization 10 minutes before and 10 minutes after urodynamic assessment |
| Measure | Description | Time Frame |
|---|---|---|
| bacterial prostate infection | urinary culture | 5-10 minutes before and after prostate massage |
| bacteriuria | urine dip stick | 5-10 minutes before and after prostate massage |
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Inclusion Criteria:
Exclusion Criteria:
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Male patients with chronic (> 1 year) spinal cord injury who perform intermittent catheterization due to neurogenic bladder dysfunction
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| Name | Affiliation | Role |
|---|---|---|
| Jürgen Pannek, Prof. | Swiss Paraplegic Center, Nottwil, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Swiss Paraplegic Centre | Nottwil | Canton of Lucerne | 6207 | Switzerland |
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|
| number of leucocytes in urine | urine dip stick | 5-10 minutes before and after prostate massage |
| number of erythrocytes in urine | urine dip stick | 5-10 minutes before and after prostate massage |
| patient characteristics | age | day 0 |
| type of neurogenic bladder dysfunction | day 0 |
| type of catheter used for intermittent catheterization | day 0 |
| annual rate of symptomatic urinary tract infections | day 0 |
| patient characteristics | sex | day 0 |
| patient characteristics | time since spinal cord injury | day 0 |
| patient characteristics | level and degree of spinal cord injury (ASIA impairment score) | day 0 |
| ID | Term |
|---|---|
| D014552 | Urinary Tract Infections |
| D001437 | Bacteriuria |
| D011776 | Pyuria |
| D011472 | Prostatitis |
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D007239 | Infections |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D019220 | High-Energy Shock Waves |
| D057928 | Intermittent Urethral Catheterization |
| ID | Term |
|---|---|
| D000069453 | Ultrasonic Waves |
| D013016 | Sound |
| D011840 | Radiation, Nonionizing |
| D011827 | Radiation |
| D055585 | Physical Phenomena |
| D014546 | Urinary Catheterization |
| D002404 | Catheterization |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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