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Most patients with spinal cord injury suffer from bladder dysfunction which may - especially in the long-term - impair renal function. Improved treatment during the last decades improved life expectancy and quality of life. This study evaluates the bladder function in the long-term after spinal cord injury.
Bladder dysfunction is a common consequence of spinal cord injury and depends on the completeness and the level of the lesion. Patients with suprasacral injury usually suffer from neurogenic detrusor overactivity mostly combined with detrusor sphincter dyssynergia. Without adequate treatment, this adverse combination puts the upper urinary tract at risk due to high intravesical pressure often causing vesico-ureteral reflux. Based on improved therapeutic options in the last decades, life expectancy and quality of life constantly increased in spinal cord injury patients. The investigators aim to evaluate the bladder function in the long-term after spinal cord injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with SCI for at least 5 years | Ages Eligibility: minimum 18 years Genders Eligibility: female and male |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Video-urodynamic examination | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Urodynamic evaluation | Max. cystometric capacity, compliance, detrusor leak point pressure | 5 years after SCI, yearly thereafter (participants are followed until death) |
| Measure | Description | Time Frame |
|---|---|---|
| secondary complications | recurrent tract infection, deterioration of the upper urinary tract | 5 years after SCI, yearly thereafter (participants are followed until death) |
| imaging of the upper urinary tract |
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Inclusion Criteria:
Exclusion Criteria:
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Ages Eligibility: minimum 18 years old Genders Eligibility: female and male
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| Name | Affiliation | Role |
|---|---|---|
| Jens Wöllner, Dr. med. | Balgrist University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital | Zurich | Canton of Zurich | 8008 | Switzerland |
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| ID | Term |
|---|---|
| D001750 | Urinary Bladder, Neurogenic |
| D010349 | Patient Compliance |
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001745 | Urinary Bladder Diseases |
| D014570 | Urologic Diseases |
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videocystography, ultrasound
| 5 years after SCI, yearly thereafter (participants are followed until death) |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |