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| Name | Class |
|---|---|
| United States Agency for International Development (USAID) | FED |
| Makerere University | OTHER |
| Harvard University | OTHER |
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The UBC was a USAID-funded longitudinal prospective cohort study of pregnant women (n= 5030) aged 15-49 years from rural North and South-Western regions of Uganda, conducted between 2014 and 2016. The aim of the UBC study was to observationally follow pregnant women and their newborns until 2 years of age and compare changes over time in communities that were part of an ongoing USAID project called the Community Connector (CC) compared to those communities that were not included in the Community Connector project.
This study aimed to assess the role of livelihoods, agriculture and nutrition in improving maternal and child nutrition and health in rural Uganda in communities that were a part of an ongoing program that was un-related to the study. The overall aim of this study was to understand the effect of participating in an ongoing program that provided support on nutrition, agriculture, water, hygiene and sanitation and the change over time in the nutritional status of mothers and children under two years of age. The specific objectives of this observational study were as follows:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women and their infants | Mothers and their infants were followed throughout the first two years of the infant's life. Data were collected at enrollment, birth, 3, 6, 9,12, 18 and 24 months from the date of delivery. |
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| Measure | Description | Time Frame |
|---|---|---|
| Percent of infants who were stunted | Percent of infants with a height-for-age less than -2 standard deviations | 0-2 years old |
| Percent of infants who were wasted | Percent of infants with a weight-for-height less than -2 standard deviations | 0-2 years old |
| Percent of infants who were underweight | Percent of infants with a weight-for-age less than -2 standard deviations | 0-2 years old |
| Infants' weight at birth (kg) | Birth weight in kilograms using a seca scale, calculated as the mean of three repeated measurements on each infant | Birth |
| Percentage of infants with low birth weight | Percentage of infants with birth weight less than 2500 grams | Birth |
| Percentage of preterm births | Percentage of infants born with a gestational age less than 259 days | Birth |
| Percentage of infants who were small-for-gestational-age | Percentage of infants at birth whose weight centiles were below the 10th percentile for their age and sex | Birth |
| Head circumference measurement (cm) |
| Measure | Description | Time Frame |
|---|---|---|
| Percent of mothers that were anemic (hemoglobin levels <11 g/dL) | Percentage of maternal anemia defined by hemoglobin levels <11 g/dL, measured using the HemoCue test. | through study completion, every 3 months |
| Percent of infants that were anemic (hemoglobin levels <11 g/dL) |
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Inclusion criteria:
Inclusion into pregnancy surveillance:
Inclusion into main study:
Exclusion criteria:
-None
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Pregnant women, children under two years, and their households in Northern and Southwestern Uganda during 2014-2016
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| Name | Affiliation | Role |
|---|---|---|
| Patrick Webb, PhD | Tufts, Friedman School of Nutrition | Study Director |
| Shibani Ghosh, PhD | Tufts, Friedman School of Nutrition | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tufts University | Boston | Massachusetts | 02111 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35239084 | Derived | Mezzano J, Namirembe G, Ausman LM, Marino-Costello E, Shrestha R, Erhardt J, Webb P, Ghosh S. Effects of Iron and Vitamin A Levels on Pregnant Women and Birth Outcomes: Complex Relationships Untangled Using a Birth Cohort Study in Uganda. Matern Child Health J. 2022 Jul;26(7):1516-1528. doi: 10.1007/s10995-022-03387-5. Epub 2022 Mar 3. | |
| 33595899 |
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De-identified data will be publicly available by the end of 2020
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End of 2020
Data will be publicly accessible
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| ID | Term |
|---|---|
| D006130 | Growth Disorders |
| D002100 | Cachexia |
| D000740 | Anemia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D015431 | Weight Loss |
| D001836 | Body Weight Changes |
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Serum samples
Infant's head circumference measured in centimeters
| 0-2 years old |
Percentage of infants with anemia defined by hemoglobin levels <11 g/dL, measured using the HemoCue test. |
| 0-2 years old |
| Concentration of ferritin (ug/L) in mothers and infants as a biomarker for iron status | Maternal and infants' serum ferritin (ug/L) measured using a sandwich enzyme-linked immunosorbent assay technique (ELISA) at the VitMin Lab in Germany | 6 months for infants, mothers at birth |
| Concentration of soluble transferrin receptor (mg/L) in mothers and infants as a biomarker for iron status | Maternal and infants' serum soluble transferrin receptor (mg/L) measured using a sandwich enzyme-linked immunosorbent assay technique (ELISA) at the VitMin Lab in Germany | 6 months for infants, mothers at birth |
| Concentration of retinol binding protein (umol/L) in mothers and infants as a biomarker for vitamin A status | Maternal and infants' serum retinol binding protein (umol/L) measured using a sandwich enzyme-linked immunosorbent assay technique (ELISA) at the VitMin Lab in Germany | 6 months for infants, mothers at birth |
| Madzorera I, Ghosh S, Wang M, Fawzi W, Isanaka S, Hertzmark E, Namirembe G, Bashaasha B, Agaba E, Turyashemererwa F, Webb P, Duggan C. Prenatal dietary diversity may influence underweight in infants in a Ugandan birth-cohort. Matern Child Nutr. 2021 Jul;17(3):e13127. doi: 10.1111/mcn.13127. Epub 2021 Feb 17. |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013851 | Thinness |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |