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In this study, the possible role of serum sodium concentration and its changes on bone markers in hospitalized, hyponatremic patients is determined. Therefore, it is investigated whether in hospitalized, hyponatremic patients the level of carboxy-terminal collagen crosslinks (CTX) is modified by changes in plasma sodium concentration, independently from the aetiology of hyponatremia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hyponatremic patients | Patients hospitalized at the University Hospital of Basel and presenting with hyponatremia will be screened for the study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sampling | Other | blood sampling for measurement of bone markers after a fasting period of at least 6 hours |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in carboxy-terminal collagen crosslinks (CTX) levels | CTX level (pg/ml) and its dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in plasma sodium level | serum sodium levels (milliequivalents per liter (mEq/L) and its dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in bone specific alkaline phosphatase (bAP) | bAP levels and their dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in osteocalcin |
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Inclusion Criteria:
Exclusion Criteria:
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Adult hospitalized patients (18 to 99-year-old), with non-hypertonic hyponatremia
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| Name | Affiliation | Role |
|---|---|---|
| Mirjam Christ-Crain, Prof. Dr. med | Endocrinology, Diabetology and Metabolism, University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Endocrinology, Diabetes and Metabolism, University Hospital Basel | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D007010 | Hyponatremia |
| ID | Term |
|---|---|
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Biological material, i.e. blood samples, will be handled according to good clinical practice and good laboratory practice. Samples will be collected in secure containers (Sarstedt Monovette®) and will be centrifuged to collect serum. Serum will be stored at - 70°C in a thermo-controlled ultra-deep freezer.
Osteocalcin (ng/mL) levels and their dynamic within 10 days of hospitalization |
| baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in procollagen type I N propeptide (PINP) (PINP) levels | PINP (ng/mL) levels and their dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in sclerostin | Sclerostin (pg/ml) levels and their dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in parathyroid hormone (PTH) | PTH (pg/ml) levels and their dynamic within 10 days of hospitalization | changes from baseline (day 1) to day 10 after inclusion in the study |
| Change in 25-hydroxy-vitamin D3 | 25-hydroxy-vitamin D3 (ng/ml) levels and their dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in calcium | Calcium (mg/dl) levels and their dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Change in phosphate levels | Phosphate(mg/dl) levels and their dynamic within 10 days of hospitalization | baseline blood exam on day 1 after inclusion and further blood collections at day 10 (+/-3 days) or at discharge, if discharge will be earlier |
| Numbers of falls | telephone interview will be performed to collect data about occurrence and numbers of falls within 30 days after enrolment | numbers of falls within 30 days after enrolment |
| Numbers of fractures | telephone interview will be performed to collect data about occurrence and numbers of fractures within 30 days after enrolment | Numbers of fractures within 30 days after inclusion in the study |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |