The Association Between Hyponatremia and Osteoporosis in Patients With Epilepsy.

The Effect of Normalization of Sodium on Bone Markers in Patients With Epilepsy. A Randomized Single-blinded Placebo-controlled Trial.

The study investigates the association between normalization of serum sodium levels and bone markers in patients with epilepsy and chronic hyponatremia.

The study is a randomized, single blinded, placebo controlled study where participants will be randomized to either treatment with salt tablets or placebo tablets through 4 months. At the beginning and end of the 4 months bone markers will be measured.

The investigators null-hypothesis is that there will be no difference in bone markers before or after the intervention.

Inclusion Criteria:

• Epilepsy requiring treatment for at least 2 years
• Known hyponatremia (2 subsequent s-sodium values < 136 mmol/l)
• Age 18-80 years
• Danish speaking
• Signed form of prior consent

Exclusion Criteria:

• Pregnancy and breastfeeding
• Known osteoporosis. DXA scan < -2.5 T-score. Z-score is used for patients 50 years or younger.
• Undergoing treatment for osteoporosis
• Undergoing treatment with salt tablets
• Known SIADH
• Severe concomitant disease such as cancer or ischemic heart disease
• Alcohol, drug or substance abuse