Evaluation of Thioldisulfide Balance in Cervical Preinvasive Lesions

Investigation of Thiol-disulfide Balance in Cervical Preinvasive Lesions

The purpose of this study is to investigate Thiol-disulfide balance in patients with cervical preinvasive lesions

To date various oxidative stress paramaters were studied in patients with cervical preinvasive lesions, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel & Neselioglu(1).

References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/ disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/ j.clinbiochem.2014.09.026.

Inclusion Criteria:

• Histopathologically confirmed diagnosis of LGSIL or HGSIL

Exclusion Criteria:

• pulmonary disease
• pulmonary hypertension
• cardiac dysfunction
• renal dysfunction
• liver disease
• chronic ishemia
• systemic inflammation
• other cervical biopy results than LGSIL or HGSIL
• concomitant malignancy
• patients who use vitamin A,C or E (antioxidant vitamins)
• patients who use smoke • patients who use drink alcohol
• patients who use addictive for any drug