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The purpose of this study is to investigate thiol-disulfide balance in early stage endometrium cancer patients.
To date various oxidative stress paramaters were studied in patients with endometrial cancer, however dynamic thiol disulfide hemostasis has not been previously investigated.
The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel & Neselioglu(1).
References
1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endometrium cancer | stage I endometrium cancer n=57 |
| |
| Healthy controls | Healthy volunteers n=60 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Disulphide(μmol/L) | Diagnostic Test | Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry |
| Measure | Description | Time Frame |
|---|---|---|
| serum native thiol level | serum native thiol level in μmol/L | preoperative in the morning or preprandial for healthy volunteers |
| serum disulphide level | serum disulphide level in μmol/L | preoperative in the morning or preprandial for healthy volunteers |
| serum total thiol level | serum total thiol level in μmol/L | preoperative in the morning or preprandial for healthy volunteers |
| the disulphide/native thiol ratio | the disulphide/native thiol ratio X (100 ) | preoperative in the morning or preprandial for healthy volunteers |
| disulphide/total thiol ratio | disulphide/total thiol ratio X (100 ) | preoperative in the morning or preprandial for healthy volunteers |
| native thiol/total thiol ratio | native thiol/total thiol ratio X (100 ) | preoperative in the morning or preprandial for healthy volunteers |
| Measure | Description | Time Frame |
|---|---|---|
| total antioxidant capacity (TAC) | TAC in mmol trolox equivalent/L | preoperative in the morning or preprandial for healthy volunteers |
| total oxidant capacity (TOC) | TOC in mmol H2O2 equivalent/L. |
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Inclusion Criteria:
• Histopathologically confirmed diagnosis of stage I endometrium cancer
Exclusion Criteria:
endometrium cancer
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The preoperative diagnosis of Endometrium cancer was made histopathologically by endometrial biopsy. An experienced pathologist performed frozen section analysis according to the surgical staging scheme of the International Federation of Gynaecology and Obstetrics.
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| Name | Affiliation | Role |
|---|---|---|
| Burak Sezgin | Mugla Sıtkı Kocman University Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mugla Sıtkı Kocman University Faculty of Medicine | Muğla | 48000 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D016889 | Endometrial Neoplasms |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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serum blood samples for aech participant
|
| Total Oxidant Capacity(μmolH2O2Equiv/L) | Diagnostic Test | Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry |
|
|
| preoperative in the morning or preprandial for healthy volunteers |
| Oxidative stress index (OSI) | OSI in mmol trolox/L. | preoperative in the morning or preprandial for healthy volunteers |
| D014591 |
| Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |