Evaluation of Dexketoprofen in Total Knee Arthroplasty

Evaluation of Dexketoprofen Given Intravenous or Intrathecal in Postoperative Pain in Patients Undergoing Total Knee Arthroplasty

Pain is a global public health issue and represents the most common reason for both physician consultation and hospital admissions. Dexketoprofen is a new NSAID treating acute postoperative pain. The purpose of this study is to evaluate the analgesic effect when it is given intravenously or as part of the local infiltration analgesia in patients under spinal anesthesia undergoing unilateral total knee arthroplasty.

Inclusion Criteria:

• unilateral total knee arthroplasty
• accept to enter the study
• ASA score I or II
• hospitalization for at least 2 days

Exclusion Criteria:

• allergy in any given medications
• active gastrointestinal bleeding or other active bleeding
• history of peptic ulcer
• renal failure
• hepatic failure
• chronic heart failure