Intraoperative Sedatives and Postoperative Pain

The Influence of Intraoperative Sedative on Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: Comparison Between Dexmedetomidine and Propofol

In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce postoperative pain in in patients undergoing the total knee arthroplasty.

Inclusion Criteria:

• Patients undergoing total knee arthroplasty
• Age: 20 - 80 yrs

Exclusion Criteria:

• ASA classification ≥ 3
• Patient who do not want sedation during the surgery
• Patient who wants general anesthesia
• Cardiovascular disease
• Liver dysfunction
• Renal dysfunction