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In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce postoperative pain in in patients undergoing the total knee arthroplasty.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine | Experimental | Patients who received dexmedetomidine during the operation |
|
| Propofol | Experimental | Patients who received propofol during the operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Intraoperative sedation using dexmedetomidine |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analogue scale | Postoperative pain score at postoperative 24 hours | Postoperative 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Rescue analgesics | Amount of rescue analgesics administered during 24 hours postoperatively | Postoperative 24 hours |
| Rescue analgesics | Amount of rescue analgesics administered during 48 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Nausea and vomiting | Incidence of nausea and vomiting during 24 hours postoperatively | Postoperative 24 hours |
| Nausea and vomiting | Incidence of nausea and vomiting during 48 hours postoperatively |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Propofol |
| Drug |
Intraoperative sedation using propofol |
|
| Postoperative 48 hours |
| Visual analogue scale | Postoperative pain score at postoperative 48 hours | Postoperative 48 hours |
| Postoperative 48 hours |
| Antiemetics | Amount of antiemetics administered during 24 hours postoperatively | Postoperative 24 hours |
| Antiemetics | Amount of antiemetics administered during 48 hours postoperatively | Postoperative 48 hours |
| Patient's satisfaction | Patient's satisfaction with the pain management using a visual analogue scale (0 = very unsatisfied, 10 = completely satisfied) | Postoperative 48 hours |
| D011183 |
| Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |