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| ID | Type | Description | Link |
|---|---|---|---|
| K23DK120517 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Speaking Activity and Talking Activity | Experimental | Participants will engage in a speaking activity first and a talking activity second. |
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| Talking Activity and Speaking Activity | Experimental | Participants will engage in a talking activity first and a speaking activity second. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Speaking Activity | Behavioral | Participants will engage in a speaking activity where they are given a topic to speak about. |
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| Measure | Description | Time Frame |
|---|---|---|
| Decision-making behavior (actual decisions) | Decisions (i.e., percent of goal-inconsistent decisions from challenge trials) | Up to 1 hour post-intervention |
| Decision-related BOLD activation (reward regions-of-interest) | Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in reward (e.g., nucleus accumbens, insula) | Up to 1 hour post-intervention |
| Decision-related BOLD activation (executive function regions-of-interest) | Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in executive function (e.g., dorsolateral prefrontal cortex, inferior frontal gyrus) | Up to 1 hour post-intervention |
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INCLUSION CRITERIA:
Inclusion Criteria for All Participants:
Additional Inclusion Criteria for Participants with Binge-Eating Disorder:
• DSM-5 binge-eating disorder
EXCLUSION CRITERIA:
Exclusion Criteria for All Participants:
Additional Exclusion Criteria for Comparison Participants:
Additional Exclusion Criteria for Participants with Binge-Eating Disorder:
Subjects must identify as female.
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| Name | Affiliation | Role |
|---|---|---|
| Kristin N Javaras, DPhil, PhD | Mclean Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McLean Hospital | Belmont | Massachusetts | 02478 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Dec 20, 2024 | Jan 8, 2026 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D056912 | Binge-Eating Disorder |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| Talking Activity | Behavioral | Participants will engage in a talking activity where they may talk about a topic of their choice. |
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