Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

Understanding The Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive Control

The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.

INCLUSION CRITERIA:

Inclusion Criteria for All Participants:

• Normal or corrected to normal vision and hearing
• Verbal and written fluency in English
• Right-handed
• Body mass index of 20-35 kg/m^2

Additional Inclusion Criteria for Participants with Binge-Eating Disorder:

• DSM-5 binge-eating disorder

EXCLUSION CRITERIA:

Exclusion Criteria for All Participants:

• Impaired cognition or other neurological/cognitive problems
• Contraindications to MRI (e.g., certain metal implants, claustrophobia)
• Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding
• Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions
• Recent low weight
• Certain medications (e.g., insulin)
• Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence
• Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods
• Current/recent suicidality
• Current/recent changes in treatment for mental illness
• Study-relevant research experience

Additional Exclusion Criteria for Comparison Participants:

• Personal history of eating disorders or recurrent binge eating
• Personal history of any other mental illness, including serious substance use problems
• First-degree relative with current or past eating or psychotic disorder
• Significant recent change in weight

Additional Exclusion Criteria for Participants with Binge-Eating Disorder:

• Severe mental illness (e.g., psychotic disorder, severe agoraphobia)
• Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety
• Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder