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| Name | Class |
|---|---|
| Else Kröner Fresenius Foundation | OTHER |
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People who suffer from binge eating disorder experience recurrent episodes of binge eating.During these episodes, they consume an unusually large amount of food in a short amount of time and experience loss of control over eating. However, why such binge eating episodes occur is still largely unknown. This makes it difficult to develop targeted treatments. In this project, the experimenters are investigating the brain mechanisms that give rise to the disorder. They hypothesize that the binge eating episodes are due to an increased variability in reward processing, which they will assess repeatedly over days. They will test this hypothesis using mathematical models based on behavioural and MRI measurements that are related to the processing of rewards.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Binge eating disorder (BED) patients | Individuals with BED diagnosis. |
| |
| non-BED controls | Individuals that do not experience binges |
| |
| subsyndromal BED controls | individuals that experience binges but do not fulfill the requirements for BED diagnosis. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI | Diagnostic Test | (Imaging while) performing reward related tasks. |
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| Measure | Description | Time Frame |
|---|---|---|
| Variability in blood-oxygen-level dependent (BOLD) signalling in the NAcc during effort allocation task | Variability of BOLD signal in the nucleus accumbens (NAcc) over time and between trials while performing an effort allocation task. The signal is measured through functional magnetic resonance imaging (fMRI) and variability is determined through model residuals. | 100 min |
| Trial-to-trial variability in reward seeking in an effort allocation task | Variability of performance is an intra-individual measure, that is defined by the residuals of a linear mixed effects model of trial-to-trial performance on the effort allocation task. | 40 min |
| Variability in BOLD signalling in the NAcc for food-cue reactivity | Variability of BOLD signal in the NAcc between blocks of food pictures. The signal is measured through fMRI and variability is determined through model residuals. | 15 |
| Measure | Description | Time Frame |
|---|---|---|
| Variability in BOLD signalling in the NAcc during non-food-cue reactivity | Variability of BOLD signal in the NAcc between blocks of non-food pictures. The signal is measured through fMRI and variability is determined through model residuals. | 5 |
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Inclusion Criteria:
Exclusion Criteria:
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The control group will consist of residents of the general area around Tübingen, Germany.
BED patients will be recruited mainly from the outpatient clinic of the Department of Clinical Psychology of Tübingen, Germany.
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| Name | Affiliation | Role |
|---|---|---|
| Nils B Kroemer, Dr | University Hospital Tuebingen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychological Institute, University of Tübingen | Tübingen | Deutschland (deu) | 72070 | Germany |
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| ID | Term |
|---|---|
| D056912 | Binge-Eating Disorder |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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