Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).

Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.

Inclusion Criteria:

• non-dialyzed patients with CKD stage 3-5
• clinical stable
• a willingness to be examined with all measurements being taken simultaneously.

Exclusion Criteria:

• systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
• severe edema within one month prior to the study
• chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
• taking immunosuppressive agents and anti-inflammatory medication chronically