Determinants of Muscle Strength in Chronic Kidney Disease

Determinants of Muscle Strength in Chronic Kidney Disease

Aim of this study is to determine in chronic kidney disease patients:

• the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment
• the relationship between voluntary muscle strength and muscle mass
• the relationship between voluntary muscle strength and lean body mass
• the correlation between voluntary muscle strength and physical activity

Aim of this study is to determine in chronic kidney disease patients:

• the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer)
• the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index)
• the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis)
• the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)

Inclusion Criteria:

• chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
• stable clinical condition (absence of infection, stroke or acute decompensation)

Exclusion Criteria:

• chronic kidney disease without extrarenal replacement therapy
• history of renal transplantation