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This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A: Sevoflurane, sufentanil and rocuronium | sevoflurane (1-3%)and sufentanil (0.5-2 mcg/kg/h) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required |
| |
| Group B: Propofol, sufentanil and rocuronium | propofol (4-12 mg/kg/h) and sufentanil (0.5-2 mcg/kg/h/) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| inhalation anesthesia | Other | sevoflurane was used to maintain anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| renal blood flow | Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s) | 2 days |
| Measure | Description | Time Frame |
|---|---|---|
| neutrophil gelatinase-associated lipocalin , NGAL | Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml) | 2 days |
| creatinine | Changes of creatinine before and 3 days after acquisition, unit (mmol/L) |
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Inclusion Criteria:
Exclusion Criteria:
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After approved by the ethics committee, sixty patients who met the inclusion criteria of this study with their parents' informed consent in Children's Hospital of Fudan University.
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| Name | Affiliation | Role |
|---|---|---|
| mazhong zhang, MD | Shanghai Children's Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital of Fudan University | Shanghai | Shanghai Municipality | China |
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| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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| ID | Term |
|---|---|
| D000769 | Anesthesia, Inhalation |
| ID | Term |
|---|---|
| D000768 | Anesthesia, General |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
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| Total intravenous anesthesia | Other | propofol was used to maintain anesthesia |
|
| 3 and 4 days |
| Mean arterial pressure | Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg) | 2 days |
| cardiopulmonary bypass (CPB) time | Cardiopulmonary bypass time was recorded, unit(minutes) | 24 hours |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |