The Protective Effects of Sevoflurane in Pediatric Cardiac Surgery

The Protective Effects of Sevoflurane Application During CPB on Pediatric Patients Underwent Cardiac Surgery: a Randomized, Controlled, Blinded Clinical Trial

During repair of a congenital heart defect the child is exposed to myocardial hypoxia. Recent studies have suggested that the paediatric myocardium is more sensitive to hypoxia and cardioplegic arrest than the adult. The protective effect of halogenated agents on ischaemia and reperfusion injury has been investigated widely in adults. The investigators hypothesis that sevoflurane applied during cardiopulmonary bypass might afford better myocardial protection during paediatric cardiac surgery.

Inclusion Criteria:

• pediatric patients (body weight < 10 kg)
• diagnosed with congenital heart diseases
• scheduled for repair operation with CPB
• in the Department of Cardiovascular Surgery, Xijing Hospital

Exclusion Criteria:

• systemic infections
• other systemic diseases